Fallout 3 and Dota 2
War... War never changes. Unless there's a big fucking fish suddenly summoning tentacles from the abyss.
that's new.
I dunno, I suppose the basic world of dota 2 after a nuclear war? No wait, Radiants ancient exploded and the Dire flooded the world. You pick one of the surviving radiant heroes to scavenge the wastes and kill creeps for bottlecaps gold pieces and xp. You meet other heroes either reveling or struggling in the post apocalyptic scene. It would be about the inter-personal communication between the heroes, and you form alliances and go beat up some dire bastards.
Or you could play from the dire perspective, when they realise that a dead world is not as fun as they'd anticipated, and now Wraith no fuck that Skeleton King has to recruit a new army to try and fix stuff. Hell would also be broken open so all the demons would be having some sort of power struggle, matching abilitied-heroes would form small gangs with personalised creeps to be used as grunts (like CM, Tusk, Winter Wyvern, Or Lina, Ember Spirit, and Phoenix)
Revelation 21:6 even fits here. It's perfect.
Or if you'd believe the comics, which i do, it would basically be an rpg set in the dota2 universe, where you eventually become a hero like the 2 unfortunate bastards who eventually ended up with the shopkeeper, from the big comic. Learn the true lore of Roshan and stuff.