This is a play about the pointlessness of life.
It is mainly about two men, Estragon and Vladmir, who are waiting for a man Godot, a play on the word God.
There are only two other characters, Pozzo, a slave-master, and his slave Lucky. If this seems like a tiny cast it's because it is, it's desolate. Lucky only has one line in the entire play, but this one line (in my version of the text) takes up 3 entire pages, it's complete gibberish.
(Also saw the Ian McKellen version, and I really wish I could find a recording of Lucky's speech, it was brilliant.)
Point is, God(ot) never shows up, Johnny Depp will never get his part. The play ends with them agreeing to leave and not come back, but they freeze, they never exit the stage.
There was also this lovely story that came out-
http://www.dailymail.co.uk/tvshowbiz/article-1277418/Sir-Ian-McKellen-mistaken-tramp-rehearses-play.html
To lighten the mood at the end, McKellen and Roger Rees did a tap dance. Y'all missed out.