I personally don't like offending people. It usually end up bad for all involved and creates a huge amount of stigmata towards the person doing the offending. Being offensive in this day and age is a bad idea.
However, it's surprising how easily offended people are.
In relation to the "Capture the Babe" mode: Yes, it is going to rustle more than a few feathers. Maybe that's part of the point (Didn't that work for Mass Effect?), a way to drum up some media. Duke Nukem Forever does seem to be adhering closely to the model that did seem to raise its popularity when that style of first person shooter was the norm. Keeping the game at its roots may be a stab at nostalgia, the target market being people who were around for those times and still game just as hard as ever. A "blast from the past", if you will.
I have a friend whom fights tooth and nail against the dying ideal of the male-centrist society and I respect her for standing up for what she believes in. On the same token, I do think she is a little too easily offended. If we take a step back and not judge media so seriously, this game can be taken in the context of good fun. So long as these chauvinistic ideals are not taken to the extreme.