RIP Lydia, died in battle in Swindler's Den. I decided to experiment with the Command system, and sent her ahead to duel a bandit with a battleaxe. When she disappeared, and the orc came after me, I cleared the room and investigated. I honestly couldn't believe she was dead. She'd fought dragons and giants and trolls with me, so it seemed impossible. But...she was gone. This triggered the beast in me, and Kematu, his Alik'r and his bandits lay in many, many pieces, strewn about the cave. I still have their scimitars and outfits as trophies. Don't get many traditionally clothed Redguards this far North, so I wasn't sure if I'd ever come across the headscarves and scimitars again.
Also Vilkas...your Lithuanian accent brightened my day, until I had the nerve to search for the Sword of Red Eagle. Turns out Red Eagle wasn't so eager to part with it, and killed Vilkas to prove a point
Narrowly averted was Torvar. He walked out on me when I was trying to frighten a priest into worshipping Molog Bal.