I learned my lesson about saving *too* frequently a long time ago, playing the original Half Life. I made a jump trying to get to a certain ladder over a Very Big Drop. I quick-saved after making the jump, assuming I was well on my way to actually connecting to the ladder... but I missed.
I quick-loaded in an attempt to try the jump again, only to discover that I had quick-saved in mid-air, Gordon still hurtling toward the ladder, but again falling short. I quick-loaded like a mad-man, over and over, in my hubris somehow thinking that I could somehow change the laws of physics and *force* myself to connect to that damn ladder. I was so close. SO CLOSE.
Since then, I have reserved frequent mashing of that quicksave button for only the craziest of crazy situations. (I'm looking at you Medal of Honor: Allied Assault's hardest difficulty, in Snipertown. 1shot from a sniper, you dead. And of course they are hiding *really* well. You know. Like snipers. Like a town full of them.)