I use Internet Explorer for reading webcomics and for doing things that I don't want my friends to know about -_-. I'll leave it to you to guess what I mean by that.
But for everything else, I use Safari. This happened after it was automatically installed on my laptop when I installed iTunes, and I was fed up of IE as it kept shutting down, cutting out, without warning whenever I browsed The Escapist. Though that problem has gone, when I tried Safari out I was hooked, and now I use it for everything apart from the above mentioned things. With webcomics, at least, it's easier because I already have a folder in my Favourites tab with the ones I read regularly, so it's easier than trying to do it all over again setting one up in Safari. I read a lot of webcomics...