Mountain lions are the bane of my existence... I have yet to meet a bear, though.
I have only experienced one glitch: While out hunting packs of wolves (collected about 60 hearts at this point), a mountain lion (my first encounter) sneaks up on my and chews on my kneecap, so I shoot at it once point blank with the double-barrel shotgun, which of course erases it from existence, only to have my character permanently stuck in "hold-your-gun-up" mode, unable to fire, reload, or take a piss, which is of course about the time another cougar shows up and decides to start browsing the lunch menu for the testicle special... so here I am, unable to run, crouch, shoot, or mount my horse, and this mountain lion is chasing my like I've got honey smoked turkey stapled to my taint; needless to say, the encounter ended with my death and the loss of all the shit I had collected over the past hour since the last save.
Lessons learned from my Purple Monkey Dishwasher experience:
Lesson 1 - Rockstar writing is superb, and any cutscene which makes me want to slap my girlfriend for interrupting is to be considered engaging and relevant to the game, and besides, I asked for a fucking sandwich 2 minutes ago, woman
Lesson 2 - Mountain lions prove my theory that all cats are demons and thus should be destroyed
Lesson 3 - Five finger fillet is not the same in real life as it was in the game, and even when using a butter knife, is extremely painful and damaging to expensive tabletop furniture
Lesson 4 - Just Cause 2 is a horrible, empty black hole of a game, and selling a black hole for 60$ is... well, genius, actually...
Lesson 5 - Plot and character development trumps customization and in-game freedom and online multiplayer any day