So, if we're defining this by the following of:Thing is Japan also does the thing where the feminine char uses her girliness to thwart evil through the power of cuteness and love and everything sweet. They don't have this requirement that to be capable you gotta be manlike.
-Female character can't be playable
-Female character can't be a damsel in distress
-Female character must be an ally
-Female character cannot be "one of the boys"
-Must be from a Western IP
Then limiting it to one female character per IP, aside from Elizabeth, I can nominate:
-Faye (Anthem)
-Kendra (Avatar)
-Nova (Battleborn)
-Tiny Tina (Borderlands)
-Eva McKenna (Command and Conquer)
-Coco Bandicoot (Crash Bandicoot)
-Ellie Langford (Dead Space)
-Ikora Rey (Destiny)
-Elizabeth McNeil (Doom)
-Amata Alvodar (Fallout)
-Hana Cole (Gears of War)
-Alyx Vance (Half-Life)
-Cortana (Halo)
-Lady of Thorns (Heroes of the Storm)
-Karan S'jet (Homeworld)
-Amy Crystal (House of the Dead)
-Evelyn Batton (Killzone)
-Freya (The Lost Vikings)
-Leela (Marathon)
-Doctor Chakwas (Mass Effect)
-Candice Parker (Mission: Impossible)
-Athena (Overwatch)
-Chandra (Perfect Dark)
-Fara (Prince of Persia)
-Samanya (Red Faction)
-Elora (Spyro the Dragon)
-Auros (Strife)
-Syl (Torchlight)
-Jaina Proudmoore (Warcraft)
-Flint (Wing Commander)
Again, all I need to do was look at an IP list and rely on memory for that.
And since some people may bring it up, there is some overlap here, since some characters are playable in some cases and not in others (see Coco and Samanya for instance). But even so, Elizabeth isn't some weird oddity in my experience.