Prime's Xuanlong Assault Rifle. Now that through Outcast trading I've acquired almost 2000 rounds of 5.56 that gun has been my best friend against just about everything. Really good for cutting through Talon patrol groups especially.
Honorable mentions go to the Hunting Rifle for bailing my ass out in the early parts of the game (one time even one-shotting a guy armed with a sniper rifle), the Silenced 10mm Pistol, The Laser Pistol (plentiful ammo and good against robots and Enclave), the Nuka Grenade, the Combat Shotgun, and the Alien Blaster.
Oh and when I do on occasion go melee it's often a tossup between the Sheish-kebab and the Ripper.
Honorable mentions go to the Hunting Rifle for bailing my ass out in the early parts of the game (one time even one-shotting a guy armed with a sniper rifle), the Silenced 10mm Pistol, The Laser Pistol (plentiful ammo and good against robots and Enclave), the Nuka Grenade, the Combat Shotgun, and the Alien Blaster.
Oh and when I do on occasion go melee it's often a tossup between the Sheish-kebab and the Ripper.