So, here's something to be extra super hyped about if they get it right:
You may be playing as a pre-war character. Yup. Before the bombs dropped.
See, Vault 111 was one of the vaults equipped with stasis chambers, so it's entirely likely that Bethesda will make you play a character who is waking up from stasis to explore this new world, which would be awesome. Also, I'm guessing if they do do that they might have a few sequences or flashbacks to old pre-war times, which will be really cool to see.
Otherwise, I can't wait to see all the flying stuff and I really hope they include some form of vehicle this time. There would be nothing cooler than Mad Maxing around the Wasteland with that dog riding shotgun (or taking the wheel when you need to shoot a deathclaw from the safety of a high speed vehicle). Still, all of the new stuff seen already makes me hyped. The hype train has officially left the station, bound for Mount Awesome, with a potential turn-off to Mount Disappointment if someone forget to make the rails work properly.
EDIT:
Also, that dog nosing the little cradle is the cutest fucking thing. Stupid cute awesome dog, you are almost definitely gonna be killed by the writers for a sad moment.