A-D. said:
Well it offered Closure to the Enclave, mainly what happened to the Troops stationed outside the Rig, since you only blow up the Rig in F2.
Alas i'd like to keep them "present". That being that they exist, instead of merely used as a boogeyman of sorts. Hell they could make the next one set so you are actually a part of the Enclave, or rather what remains of it. Basicly like the Remnants, but starting over. Chicago would work for that one. And the "big bad enemy" is actually the Brotherhood this time around. The Van Buren Design Documents do include the Circle of Steel, a much darker Version of the Brotherhood which could just as well work. Include the shift from one to the other, and allow your Character to make a Impact, helping them towards either side, Brotherhood or Circle and "rebuild". If Tactics is considered entirely Canon, the Midwestern Brotherhood laid the groundwork for the only existing Civilization after the War, that being a actually controlled and civilized Area that gets as close to Old World Tech as possible.
Perhaps the Enclave Remnants, which you could play as, help make it happen, make up for the Shit they did basicly. Its a Option at least. As long as they dont bring back Vault 0 anyways.
But other than that, well yeah, Florida, Everglades, Arizona or Montana could be good Locations to base a future Installment in.