...An epic sort of Pokemon game might work, but you have to ask yourself a few questions.
1) How is it that Pokemon can do the things they do?
2) Why isn't there a police force to control certain things?
3) Why is it that there are only one of certain Pokemon in the world?
4) If there is only one, why isn't it illegal to catch and train it?
5) If some of these Pokemon are so awesomoely powerful, then why is it that they don't go on a rampage and destroy entire countries?
6) How big is Kanto, really?
7) Why don't wild Pokemon attack people? If they do, then how was the planet domesticated as well as it is?
8) How does a Pokeball work? How is it that you can make one out of an acorn shell?
9) If pokemon can do all these fantastic things, why can't people?
10) How would having extraordinarally powerful animals at your disposal change a general society?
If you couldn't tell, I've thought about this. Not really a lot, either; I just notice plotholes within plotholes.
Oh well. I stopped playing after crystal, so it's no biggie to me.