I could list all the manly tear scenes in ME3, but I want to get some sleep tonight. I'll just say that the end made me break down (in my defense I was up for 34 hours at that point, so my emotions were raw).
Other games have drawn the manly tear once or twice, but ME3 in my true weakness. It's a raw, exposed emotional nerve.
Although mark my words, if I ever beat Civ 5 on Deity I will unleash a flood of tears.