Definitely:
Prototype 2, the dev commentaries just have me sold, they've really thought every detail through it seems.
Assassin's Creed III, as I am and shall forever be, a screed fanboy.
Medal of Honor: The Next One (What does this one make it, eleven?), I loved the reboot and I very much look forward to what Danger Close comes up with next. (if it's out for 2012, which it probably will be)
What I've got an eye on:
Dishonored, I've got a hard on for stealth games.
Hitman: Absolution, see above.
If it's out for 2012, Splinter Cell 6, again, see above.
Twisted Metal, my brother and I played three when we were kids, so I kinda have to, for nostalgia's sake.
Syndicate, I wasn't around at the time of the original, but this looks like it could be good.
Max Payne 3, the tech demo caught my eye, it looked amazing.
Tomb Raider, I really don't know about this one, it kinda looks unique, so I've got an eye on it, but the gameplay looked quick-timey, which granted I don't have the hate on for QTEs that most gamers seem too, but it didn't look too interesting and that one trailer really didn't raise my hopes for Lara being a strong female character, It only reminded me of the horror that was Metroid other m.
Oh, and Metal Gear Solid Rising if they get sober and realise how badly they've fucked up with Metal Gear Rising: I refuse to say the subtitle.